Unprocessed Viral DNA Could Be the Primary Target of the HIV-1 Integrase Inhibitor Raltegravir

Integration of HIV DNA into host chromosome requires a 3′-processing (3′-P) and a strand transfer (ST) reactions catalyzed by virus integrase (IN). Raltegravir (RAL), commonly used in AIDS therapy, belongs to the family of IN ST inhibitors (INSTIs) acting on IN-viral DNA complexes (intasomes). Howev...

Descripción completa

Detalles Bibliográficos
Autores principales: Ammar, Farah F., Abdel-Azeim, Safwat, Zargarian, Loussinée, Hobaika, Zeina, Maroun, Richard G., Fermandjian, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388078/
https://www.ncbi.nlm.nih.gov/pubmed/22768342
http://dx.doi.org/10.1371/journal.pone.0040223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388078/
https://www.ncbi.nlm.nih.gov/pubmed/22768342
http://dx.doi.org/10.1371/journal.pone.0040223

Ejemplares similares