Dual Hypocretin Receptor Antagonism Is More Effective for Sleep Promotion than Antagonism of Either Receptor Alone

The hypocretin (orexin) system is involved in sleep/wake regulation, and antagonists of both hypocretin receptor type 1 (HCRTR1) and/or HCRTR2 are considered to be potential hypnotic medications. It is currently unclear whether blockade of either or both receptors is more effective for promoting sle...

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Detalles Bibliográficos
Autores principales: Morairty, Stephen R., Revel, Florent G., Malherbe, Pari, Moreau, Jean-Luc, Valladao, Daniel, Wettstein, Joseph G., Kilduff, Thomas S., Borroni, Edilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388080/
https://www.ncbi.nlm.nih.gov/pubmed/22768296
http://dx.doi.org/10.1371/journal.pone.0039131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388080/
https://www.ncbi.nlm.nih.gov/pubmed/22768296
http://dx.doi.org/10.1371/journal.pone.0039131

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