Dimerization and Heme Binding Are Conserved in Amphibian and Starfish Homologues of the microRNA Processing Protein DGCR8

Human DiGeorge Critical Region 8 (DGCR8) is an essential microRNA (miRNA) processing factor that is activated via direct interaction with Fe(III) heme. In order for DGCR8 to bind heme, it must dimerize using a dimerization domain embedded within its heme-binding domain (HBD). We previously reported...

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Detalles Bibliográficos
Autores principales: Senturia, Rachel, Laganowsky, Arthur, Barr, Ian, Scheidemantle, Brooke D., Guo, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388087/
https://www.ncbi.nlm.nih.gov/pubmed/22768307
http://dx.doi.org/10.1371/journal.pone.0039688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388087/
https://www.ncbi.nlm.nih.gov/pubmed/22768307
http://dx.doi.org/10.1371/journal.pone.0039688

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