Acute Knockdown of Uncoupling Protein-2 Increases Uncoupling via the Adenine Nucleotide Transporter and Decreases Oxidative Stress in Diabetic Kidneys

Increased O(2) metabolism resulting in chronic hypoxia is common in models of endstage renal disease. Mitochondrial uncoupling increases O(2) consumption but the ensuing reduction in mitochondrial membrane potential may limit excessive oxidative stress. The present study addressed the hypothesis tha...

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Detalles Bibliográficos
Autores principales: Friederich-Persson, Malou, Aslam, Shakil, Nordquist, Lina, Welch, William J., Wilcox, Christopher S., Palm, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388100/
https://www.ncbi.nlm.nih.gov/pubmed/22768304
http://dx.doi.org/10.1371/journal.pone.0039635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388100/
https://www.ncbi.nlm.nih.gov/pubmed/22768304
http://dx.doi.org/10.1371/journal.pone.0039635

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