Experimental adaptation of an influenza H5 haemagglutinin (HA) confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans, but currently do not transmit efficiently among humans. The viral haemagglutinin (HA) protein is a known host range determinant since it mediates virus binding to host-specific cellular receptors(1–3). Here, we therefore as...

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Detalles Bibliográficos
Autores principales: Imai, Masaki, Watanabe, Tokiko, Hatta, Masato, Das, Subash C., Ozawa, Makoto, Shinya, Kyoko, Zhong, Gongxun, Hanson, Anthony, Katsura, Hiroaki, Watanabe, Shinji, Li, Chengjun, Kawakami, Eiryo, Yamada, Shinya, Kiso, Maki, Suzuki, Yasuo, Maher, Eileen A., Neumann, Gabriele, Kawaoka, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388103/
https://www.ncbi.nlm.nih.gov/pubmed/22722205
http://dx.doi.org/10.1038/nature10831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388103/
https://www.ncbi.nlm.nih.gov/pubmed/22722205
http://dx.doi.org/10.1038/nature10831

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