Mantle cell lymphoma-like lymphomas in c-myc-3'RR/p53(+/−) mice and c-myc-3'RR/Cdk4(R24C) mice: differential oncogenic mechanisms but similar cellular origin

Mantle cell lymphoma (MCL) is a malignant lymphoproliferative B-cell disorder that does not occur spontaneously in mice but experimental mice model have been developed. Recently two different mice models prone to develop MCL-like lymphomas were generated: c-myc-3'RR/Cdk4(R24C) mice and c-myc-3&...

Descripción completa

Detalles Bibliográficos
Autores principales: Rouaud, Pauline, Fiancette, Rémi, Vincent-Fabert, Christelle, Magnone, Virginie, Cogné, Michel, Dubus, Pierre, Denizot, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Methodological Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388189/
https://www.ncbi.nlm.nih.gov/pubmed/22592113
Descripción
Sumario:Mantle cell lymphoma (MCL) is a malignant lymphoproliferative B-cell disorder that does not occur spontaneously in mice but experimental mice model have been developed. Recently two different mice models prone to develop MCL-like lymphomas were generated: c-myc-3'RR/Cdk4(R24C) mice and c-myc-3'RR/p53(+/−) mice. Comparison of their gene expression profiles does not highlight specific differences other than those in relation with their specific mutational status (i.e., Cdk4(R24C) mutation or p53 mutation). We propose that similarly to typical human MCL and its blastoid or cyclin-D1 variants that correspond to the same genetic entity, MCL-like lymphomas of c-myc-3'RR/p53(+/−) mice and c-myc-3'RR/Cdk4(R24C) mice represent a spectrum of the same entity.

Ejemplares similares