Mantle cell lymphoma-like lymphomas in c-myc-3'RR/p53(+/−) mice and c-myc-3'RR/Cdk4(R24C) mice: differential oncogenic mechanisms but similar cellular origin

Mantle cell lymphoma (MCL) is a malignant lymphoproliferative B-cell disorder that does not occur spontaneously in mice but experimental mice model have been developed. Recently two different mice models prone to develop MCL-like lymphomas were generated: c-myc-3'RR/Cdk4(R24C) mice and c-myc-3&...

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Autores principales: Rouaud, Pauline, Fiancette, Rémi, Vincent-Fabert, Christelle, Magnone, Virginie, Cogné, Michel, Dubus, Pierre, Denizot, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Methodological Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388189/
https://www.ncbi.nlm.nih.gov/pubmed/22592113
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author Rouaud, Pauline
Fiancette, Rémi
Vincent-Fabert, Christelle
Magnone, Virginie
Cogné, Michel
Dubus, Pierre
Denizot, Yves
author_facet Rouaud, Pauline
Fiancette, Rémi
Vincent-Fabert, Christelle
Magnone, Virginie
Cogné, Michel
Dubus, Pierre
Denizot, Yves
author_sort Rouaud, Pauline
collection PubMed
description Mantle cell lymphoma (MCL) is a malignant lymphoproliferative B-cell disorder that does not occur spontaneously in mice but experimental mice model have been developed. Recently two different mice models prone to develop MCL-like lymphomas were generated: c-myc-3'RR/Cdk4(R24C) mice and c-myc-3'RR/p53(+/−) mice. Comparison of their gene expression profiles does not highlight specific differences other than those in relation with their specific mutational status (i.e., Cdk4(R24C) mutation or p53 mutation). We propose that similarly to typical human MCL and its blastoid or cyclin-D1 variants that correspond to the same genetic entity, MCL-like lymphomas of c-myc-3'RR/p53(+/−) mice and c-myc-3'RR/Cdk4(R24C) mice represent a spectrum of the same entity.
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spelling pubmed-33881892012-07-06 Mantle cell lymphoma-like lymphomas in c-myc-3'RR/p53(+/−) mice and c-myc-3'RR/Cdk4(R24C) mice: differential oncogenic mechanisms but similar cellular origin Rouaud, Pauline Fiancette, Rémi Vincent-Fabert, Christelle Magnone, Virginie Cogné, Michel Dubus, Pierre Denizot, Yves Oncotarget Methodological Reports Mantle cell lymphoma (MCL) is a malignant lymphoproliferative B-cell disorder that does not occur spontaneously in mice but experimental mice model have been developed. Recently two different mice models prone to develop MCL-like lymphomas were generated: c-myc-3'RR/Cdk4(R24C) mice and c-myc-3'RR/p53(+/−) mice. Comparison of their gene expression profiles does not highlight specific differences other than those in relation with their specific mutational status (i.e., Cdk4(R24C) mutation or p53 mutation). We propose that similarly to typical human MCL and its blastoid or cyclin-D1 variants that correspond to the same genetic entity, MCL-like lymphomas of c-myc-3'RR/p53(+/−) mice and c-myc-3'RR/Cdk4(R24C) mice represent a spectrum of the same entity. Impact Journals LLC 2012-05-15 /pmc/articles/PMC3388189/ /pubmed/22592113 Text en Copyright: © 2012 Rouaud et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Methodological Reports
Rouaud, Pauline
Fiancette, Rémi
Vincent-Fabert, Christelle
Magnone, Virginie
Cogné, Michel
Dubus, Pierre
Denizot, Yves
Mantle cell lymphoma-like lymphomas in c-myc-3'RR/p53(+/−) mice and c-myc-3'RR/Cdk4(R24C) mice: differential oncogenic mechanisms but similar cellular origin
title Mantle cell lymphoma-like lymphomas in c-myc-3'RR/p53(+/−) mice and c-myc-3'RR/Cdk4(R24C) mice: differential oncogenic mechanisms but similar cellular origin
title_full Mantle cell lymphoma-like lymphomas in c-myc-3'RR/p53(+/−) mice and c-myc-3'RR/Cdk4(R24C) mice: differential oncogenic mechanisms but similar cellular origin
title_fullStr Mantle cell lymphoma-like lymphomas in c-myc-3'RR/p53(+/−) mice and c-myc-3'RR/Cdk4(R24C) mice: differential oncogenic mechanisms but similar cellular origin
title_full_unstemmed Mantle cell lymphoma-like lymphomas in c-myc-3'RR/p53(+/−) mice and c-myc-3'RR/Cdk4(R24C) mice: differential oncogenic mechanisms but similar cellular origin
title_short Mantle cell lymphoma-like lymphomas in c-myc-3'RR/p53(+/−) mice and c-myc-3'RR/Cdk4(R24C) mice: differential oncogenic mechanisms but similar cellular origin
title_sort mantle cell lymphoma-like lymphomas in c-myc-3'rr/p53(+/−) mice and c-myc-3'rr/cdk4(r24c) mice: differential oncogenic mechanisms but similar cellular origin
topic Methodological Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388189/
https://www.ncbi.nlm.nih.gov/pubmed/22592113
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