Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress

Endoplasmic reticulum (ER) stress triggers apoptosis by activating Bim in diverse types of cells, which involves dephosphorylation of Bim(EL) by protein phosphatase 2A (PP2A). However, melanoma cells are largely resistant to ER stress-induced apoptosis, suggesting that Bim activation is suppressed i...

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Detalles Bibliográficos
Autores principales: Tay, K H, Jin, L, Tseng, H-Y, Jiang, C C, Ye, Y, Thorne, R F, Liu, T, Guo, S T, Verrills, N M, Hersey, P, Zhang, X D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388246/
https://www.ncbi.nlm.nih.gov/pubmed/22739989
http://dx.doi.org/10.1038/cddis.2012.79

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388246/
https://www.ncbi.nlm.nih.gov/pubmed/22739989
http://dx.doi.org/10.1038/cddis.2012.79

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