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Relative Copy Number Variations of CYP2C19 in South Indian Population

CYP2C19 is a polymorphic enzyme involved in the metabolism of clinically important drugs. Genotype-phenotype association studies of CYP2C19 have reported wide ranges in the metabolic ratios of its substrates. These discrepancies could be attributed to the variations in the promoter region and this a...

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Autores principales: Devendran, Anichavezhi, Uppugunduri, Chakradhara Rao Satyanarayana, Sundaram, Rajan, Shewade, Deepak Gopal, Rajagopal, Krishnamoorthy, Chandrasekaran, Adithan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389726/
https://www.ncbi.nlm.nih.gov/pubmed/22792463
http://dx.doi.org/10.1155/2012/643856
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author Devendran, Anichavezhi
Uppugunduri, Chakradhara Rao Satyanarayana
Sundaram, Rajan
Shewade, Deepak Gopal
Rajagopal, Krishnamoorthy
Chandrasekaran, Adithan
author_facet Devendran, Anichavezhi
Uppugunduri, Chakradhara Rao Satyanarayana
Sundaram, Rajan
Shewade, Deepak Gopal
Rajagopal, Krishnamoorthy
Chandrasekaran, Adithan
author_sort Devendran, Anichavezhi
collection PubMed
description CYP2C19 is a polymorphic enzyme involved in the metabolism of clinically important drugs. Genotype-phenotype association studies of CYP2C19 have reported wide ranges in the metabolic ratios of its substrates. These discrepancies could be attributed to the variations in the promoter region and this aspect has been reported recently. The observations in the recent reports on the influence of promoter region variants on the metabolism of CYP2C19 substrates might also have been influenced by the copy number variations of CYP2C19. In this paper, we describe copy number variations of CYP2C19 using real-time polymerase chain reaction by comparative Ct method. No copy number variations were observed in the south Indian population indicating the observed discrepancies in genotype-phenotype association studies might be due to the regulatory region polymorphisms as reported earlier.
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spelling pubmed-33897262012-07-12 Relative Copy Number Variations of CYP2C19 in South Indian Population Devendran, Anichavezhi Uppugunduri, Chakradhara Rao Satyanarayana Sundaram, Rajan Shewade, Deepak Gopal Rajagopal, Krishnamoorthy Chandrasekaran, Adithan Mol Biol Int Research Article CYP2C19 is a polymorphic enzyme involved in the metabolism of clinically important drugs. Genotype-phenotype association studies of CYP2C19 have reported wide ranges in the metabolic ratios of its substrates. These discrepancies could be attributed to the variations in the promoter region and this aspect has been reported recently. The observations in the recent reports on the influence of promoter region variants on the metabolism of CYP2C19 substrates might also have been influenced by the copy number variations of CYP2C19. In this paper, we describe copy number variations of CYP2C19 using real-time polymerase chain reaction by comparative Ct method. No copy number variations were observed in the south Indian population indicating the observed discrepancies in genotype-phenotype association studies might be due to the regulatory region polymorphisms as reported earlier. Hindawi Publishing Corporation 2012 2012-06-25 /pmc/articles/PMC3389726/ /pubmed/22792463 http://dx.doi.org/10.1155/2012/643856 Text en Copyright © 2012 Anichavezhi Devendran et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Devendran, Anichavezhi
Uppugunduri, Chakradhara Rao Satyanarayana
Sundaram, Rajan
Shewade, Deepak Gopal
Rajagopal, Krishnamoorthy
Chandrasekaran, Adithan
Relative Copy Number Variations of CYP2C19 in South Indian Population
title Relative Copy Number Variations of CYP2C19 in South Indian Population
title_full Relative Copy Number Variations of CYP2C19 in South Indian Population
title_fullStr Relative Copy Number Variations of CYP2C19 in South Indian Population
title_full_unstemmed Relative Copy Number Variations of CYP2C19 in South Indian Population
title_short Relative Copy Number Variations of CYP2C19 in South Indian Population
title_sort relative copy number variations of cyp2c19 in south indian population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389726/
https://www.ncbi.nlm.nih.gov/pubmed/22792463
http://dx.doi.org/10.1155/2012/643856
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