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Relative Copy Number Variations of CYP2C19 in South Indian Population
CYP2C19 is a polymorphic enzyme involved in the metabolism of clinically important drugs. Genotype-phenotype association studies of CYP2C19 have reported wide ranges in the metabolic ratios of its substrates. These discrepancies could be attributed to the variations in the promoter region and this a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389726/ https://www.ncbi.nlm.nih.gov/pubmed/22792463 http://dx.doi.org/10.1155/2012/643856 |
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author | Devendran, Anichavezhi Uppugunduri, Chakradhara Rao Satyanarayana Sundaram, Rajan Shewade, Deepak Gopal Rajagopal, Krishnamoorthy Chandrasekaran, Adithan |
author_facet | Devendran, Anichavezhi Uppugunduri, Chakradhara Rao Satyanarayana Sundaram, Rajan Shewade, Deepak Gopal Rajagopal, Krishnamoorthy Chandrasekaran, Adithan |
author_sort | Devendran, Anichavezhi |
collection | PubMed |
description | CYP2C19 is a polymorphic enzyme involved in the metabolism of clinically important drugs. Genotype-phenotype association studies of CYP2C19 have reported wide ranges in the metabolic ratios of its substrates. These discrepancies could be attributed to the variations in the promoter region and this aspect has been reported recently. The observations in the recent reports on the influence of promoter region variants on the metabolism of CYP2C19 substrates might also have been influenced by the copy number variations of CYP2C19. In this paper, we describe copy number variations of CYP2C19 using real-time polymerase chain reaction by comparative Ct method. No copy number variations were observed in the south Indian population indicating the observed discrepancies in genotype-phenotype association studies might be due to the regulatory region polymorphisms as reported earlier. |
format | Online Article Text |
id | pubmed-3389726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33897262012-07-12 Relative Copy Number Variations of CYP2C19 in South Indian Population Devendran, Anichavezhi Uppugunduri, Chakradhara Rao Satyanarayana Sundaram, Rajan Shewade, Deepak Gopal Rajagopal, Krishnamoorthy Chandrasekaran, Adithan Mol Biol Int Research Article CYP2C19 is a polymorphic enzyme involved in the metabolism of clinically important drugs. Genotype-phenotype association studies of CYP2C19 have reported wide ranges in the metabolic ratios of its substrates. These discrepancies could be attributed to the variations in the promoter region and this aspect has been reported recently. The observations in the recent reports on the influence of promoter region variants on the metabolism of CYP2C19 substrates might also have been influenced by the copy number variations of CYP2C19. In this paper, we describe copy number variations of CYP2C19 using real-time polymerase chain reaction by comparative Ct method. No copy number variations were observed in the south Indian population indicating the observed discrepancies in genotype-phenotype association studies might be due to the regulatory region polymorphisms as reported earlier. Hindawi Publishing Corporation 2012 2012-06-25 /pmc/articles/PMC3389726/ /pubmed/22792463 http://dx.doi.org/10.1155/2012/643856 Text en Copyright © 2012 Anichavezhi Devendran et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Devendran, Anichavezhi Uppugunduri, Chakradhara Rao Satyanarayana Sundaram, Rajan Shewade, Deepak Gopal Rajagopal, Krishnamoorthy Chandrasekaran, Adithan Relative Copy Number Variations of CYP2C19 in South Indian Population |
title | Relative Copy Number Variations of CYP2C19 in South Indian Population |
title_full | Relative Copy Number Variations of CYP2C19 in South Indian Population |
title_fullStr | Relative Copy Number Variations of CYP2C19 in South Indian Population |
title_full_unstemmed | Relative Copy Number Variations of CYP2C19 in South Indian Population |
title_short | Relative Copy Number Variations of CYP2C19 in South Indian Population |
title_sort | relative copy number variations of cyp2c19 in south indian population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389726/ https://www.ncbi.nlm.nih.gov/pubmed/22792463 http://dx.doi.org/10.1155/2012/643856 |
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