Urinary Copper Elevation in a Mouse Model of Wilson's Disease Is a Regulated Process to Specifically Decrease the Hepatic Copper Load

Body copper homeostasis is regulated by the liver, which removes excess copper via bile. In Wilson's disease (WD), this function is disrupted due to inactivation of the copper transporter ATP7B resulting in hepatic copper overload. High urinary copper is a diagnostic feature of WD linked to liv...

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Detalles Bibliográficos
Autores principales: Gray, Lawrence W., Peng, Fangyu, Molloy, Shannon A., Pendyala, Venkata S., Muchenditsi, Abigael, Muzik, Otto, Lee, Jaekwon, Kaplan, Jack H., Lutsenko, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390108/
https://www.ncbi.nlm.nih.gov/pubmed/22802922
http://dx.doi.org/10.1371/journal.pone.0038327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390108/
https://www.ncbi.nlm.nih.gov/pubmed/22802922
http://dx.doi.org/10.1371/journal.pone.0038327

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