High-Affinity Target Binding Engineered via Fusion of a Single-Domain Antibody Fragment with a Ligand-Tailored SH3 Domain

Monoclonal and recombinant antibodies are ubiquitous tools in diagnostics, therapeutics, and biotechnology. However, their biochemical properties lack optimal robustness, their bacterial production is not easy, and possibilities to create multifunctional fusion proteins based on them are limited. Mo...

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Detalles Bibliográficos
Autores principales: Järviluoma, Annika, Strandin, Tomas, Lülf, Sebastian, Bouchet, Jérôme, Mäkelä, Anna R., Geyer, Matthias, Benichou, Serge, Saksela, Kalle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390362/
https://www.ncbi.nlm.nih.gov/pubmed/22792285
http://dx.doi.org/10.1371/journal.pone.0040331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390362/
https://www.ncbi.nlm.nih.gov/pubmed/22792285
http://dx.doi.org/10.1371/journal.pone.0040331

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