A Regulatory Loop Involving PAX6, MITF, and WNT Signaling Controls Retinal Pigment Epithelium Development

The separation of the optic neuroepithelium into future retina and retinal pigment epithelium (RPE) is a critical event in early eye development in vertebrates. Here we show in mice that the transcription factor PAX6, well-known for its retina-promoting activity, also plays a crucial role in early p...

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Detalles Bibliográficos
Autores principales: Bharti, Kapil, Gasper, Melanie, Ou, Jingxing, Brucato, Martha, Clore-Gronenborn, Katharina, Pickel, James, Arnheiter, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390378/
https://www.ncbi.nlm.nih.gov/pubmed/22792072
http://dx.doi.org/10.1371/journal.pgen.1002757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390378/
https://www.ncbi.nlm.nih.gov/pubmed/22792072
http://dx.doi.org/10.1371/journal.pgen.1002757

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