The Cholesterol-Dependent Cytolysin Signature Motif: A Critical Element in the Allosteric Pathway that Couples Membrane Binding to Pore Assembly

The cholesterol-dependent cytolysins (CDCs) constitute a family of pore-forming toxins that contribute to the pathogenesis of a large number of Gram-positive bacterial pathogens.The most highly conserved region in the primary structure of the CDCs is the signature undecapeptide sequence (ECTGLAWEWWR...

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Detalles Bibliográficos
Autores principales: Dowd, Kelley J., Tweten, Rodney K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390400/
https://www.ncbi.nlm.nih.gov/pubmed/22792065
http://dx.doi.org/10.1371/journal.ppat.1002787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390400/
https://www.ncbi.nlm.nih.gov/pubmed/22792065
http://dx.doi.org/10.1371/journal.ppat.1002787

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