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Proteasome-Dependent Disruption of the E3 Ubiquitin Ligase Anaphase-Promoting Complex by HCMV Protein pUL21a

The anaphase-promoting complex (APC) is an E3 ubiquitin ligase which controls ubiquitination and degradation of multiple cell cycle regulatory proteins. During infection, human cytomegalovirus (HCMV), a widespread pathogen, not only phosphorylates the APC coactivator Cdh1 via the multifunctional vir...

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Detalles Bibliográficos
Autores principales:	Fehr, Anthony R., Gualberto, Nathaniel C., Savaryn, John Paul, Terhune, Scott S., Yu, Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390409/ https://www.ncbi.nlm.nih.gov/pubmed/22792066 http://dx.doi.org/10.1371/journal.ppat.1002789

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