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How (specific) would you like your T-cells today? Generating T-cell therapeutic function through TCR-gene transfer
T-cells are central players in the immune response against both pathogens and cancer. Their specificity is solely dictated by the T-cell receptor (TCR) they clonally express. As such, the genetic modification of T lymphocytes using pathogen- or cancer-specific TCRs represents an appealing strategy t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Research Foundation
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390604/ https://www.ncbi.nlm.nih.gov/pubmed/22783259 http://dx.doi.org/10.3389/fimmu.2012.00186 |