Sequestration of Sup35 by Aggregates of huntingtin Fragments Causes Toxicity of [PSI(+)] Yeast

Expression of huntingtin fragments with 103 glutamines (HttQ103) is toxic in yeast containing either the [PIN(+)] prion, which is the amyloid form of Rnq1, or [PSI(+)] prion, which is the amyloid form of Sup35. We find that HttQP103, which has a polyproline region at the C-terminal end of the polyQ...

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Detalles Bibliográficos
Autores principales: Zhao, Xiaohong, Park, Yang-Nim, Todor, Horia, Moomau, Christine, Masison, Daniel, Eisenberg, Evan, Greene, Lois E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390612/
https://www.ncbi.nlm.nih.gov/pubmed/22573320
http://dx.doi.org/10.1074/jbc.M111.287748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390612/
https://www.ncbi.nlm.nih.gov/pubmed/22573320
http://dx.doi.org/10.1074/jbc.M111.287748

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