Reduced Na(+) and higher K(+) channel expression and function contribute to right ventricular origin of arrhythmias in Scn5a+/− mice

Brugada syndrome (BrS) is associated with ventricular tachycardia originating particularly in the right ventricle (RV). We explore electrophysiological features predisposing to such arrhythmic tendency and their possible RV localization in a heterozygotic Scn5a+/− murine model. Na(v)1.5 mRNA and pro...

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Detalles Bibliográficos
Autores principales: Martin, Claire A., Siedlecka, Urszula, Kemmerich, Kristin, Lawrence, Jason, Cartledge, James, Guzadhur, Laila, Brice, Nicola, Grace, Andrew A., Schwiening, Christof, Terracciano, Cesare M., Huang, Christopher L.-H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390792/
https://www.ncbi.nlm.nih.gov/pubmed/22773948
http://dx.doi.org/10.1098/rsob.120072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390792/
https://www.ncbi.nlm.nih.gov/pubmed/22773948
http://dx.doi.org/10.1098/rsob.120072

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