Relationship of Metabolism and Cell Proliferation to the Mode of Action of Fluensulfone-Induced Mouse Lung Tumors: Analysis of Their Human Relevance Using the IPCS Framework

Species-specific lung tumors in the mouse are induced by a number of chemicals. The underlying cause appears to be a high metabolic activity of mouse lung, due to relatively high abundance of Clara cells in mice compared with humans and the mouse-specific cytochrome P450 isoform 2f2 in the Clara cel...

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Detalles Bibliográficos
Autores principales: Strupp, Christian, Banas, Deborah A., Cohen, Samuel M., Gordon, Elliot B., Jaeger, Martina, Weber, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Safety Evaluation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391030/
https://www.ncbi.nlm.nih.gov/pubmed/22491425
http://dx.doi.org/10.1093/toxsci/kfs127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391030/
https://www.ncbi.nlm.nih.gov/pubmed/22491425
http://dx.doi.org/10.1093/toxsci/kfs127

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