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Structure of the Glycosyltransferase EryCIII in Complex with its Activating P450 Homologue EryCII

In the biosynthesis of the clinically important antibiotic erythromycin D, the glycosyltransferase (GT) EryCIII, in concert with its partner EryCII, attaches a nucleotide-activated sugar to the macrolide scaffold with high specificity. To understand the role of EryCII, we have determined the crystal...

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Detalles Bibliográficos
Autores principales: Moncrieffe, Martin C., Fernandez, Maria-Jose, Spiteller, Dieter, Matsumura, Hiroyoshi, Gay, Nicholas J., Luisi, Ben F., Leadlay, Peter F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391682/
https://www.ncbi.nlm.nih.gov/pubmed/22056329
http://dx.doi.org/10.1016/j.jmb.2011.10.036