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Basic research in HIV vaccinology is hampered by reductionist thinking
This review describes the structure-based reverse vaccinology approach aimed at developing vaccine immunogens capable of inducing antibodies that broadly neutralize HIV-1. Some basic principles of protein immunochemistry are reviewed and the implications of the extensive polyspecificity of antibodie...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Research Foundation
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391733/ https://www.ncbi.nlm.nih.gov/pubmed/22787464 http://dx.doi.org/10.3389/fimmu.2012.00194 |