Enhanced J-protein interaction and compromised protein stability of mtHsp70 variants lead to mitochondrial dysfunction in Parkinson's disease

Parkinson's disease (PD) is the second most prevalent progressive neurological disorder commonly associated with impaired mitochondrial function in dopaminergic neurons. Although familial PD is multifactorial in nature, a recent genetic screen involving PD patients identified two mitochondrial...

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Detalles Bibliográficos
Autores principales: Goswami, Arvind Vittal, Samaddar, Madhuja, Sinha, Devanjan, Purushotham, Jaya, D'Silva, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392108/
https://www.ncbi.nlm.nih.gov/pubmed/22544056
http://dx.doi.org/10.1093/hmg/dds162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392108/
https://www.ncbi.nlm.nih.gov/pubmed/22544056
http://dx.doi.org/10.1093/hmg/dds162

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