The E3-Ubiquitin Ligase TRIM50 Interacts with HDAC6 and p62, and Promotes the Sequestration and Clearance of Ubiquitinated Proteins into the Aggresome

In this study we report that, in response to proteasome inhibition, the E3-Ubiquitin ligase TRIM50 localizes to and promotes the recruitment and aggregation of polyubiquitinated proteins to the aggresome. Using Hdac6-deficient mouse embryo fibroblasts (MEF) we show that this localization is mediated...

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Detalles Bibliográficos
Autores principales: Fusco, Carmela, Micale, Lucia, Egorov, Mikhail, Monti, Maria, D’Addetta, Ester Valentina, Augello, Bartolomeo, Cozzolino, Flora, Calcagnì, Alessia, Fontana, Andrea, Polishchuk, Roman S., Didelot, Gerard, Reymond, Alexandre, Pucci, Piero, Merla, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392214/
https://www.ncbi.nlm.nih.gov/pubmed/22792322
http://dx.doi.org/10.1371/journal.pone.0040440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392214/
https://www.ncbi.nlm.nih.gov/pubmed/22792322
http://dx.doi.org/10.1371/journal.pone.0040440

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