Parkin Promotes Degradation of the Mitochondrial Pro-Apoptotic ARTS Protein

Parkinson’s disease (PD) is associated with excessive cell death causing selective loss of dopaminergic neurons. Dysfunction of the Ubiquitin Proteasome System (UPS) is associated with the pathophysiology of PD. Mutations in Parkin which impair its E3-ligase activity play a major role in the pathoge...

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Detalles Bibliográficos
Autores principales: Kemeny, Stav, Dery, Dikla, Loboda, Yelena, Rovner, Marshall, Lev, Tali, Zuri, Dotan, Finberg, John P. M., Larisch, Sarit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392246/
https://www.ncbi.nlm.nih.gov/pubmed/22792159
http://dx.doi.org/10.1371/journal.pone.0038837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392246/
https://www.ncbi.nlm.nih.gov/pubmed/22792159
http://dx.doi.org/10.1371/journal.pone.0038837

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