Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes

INTRODUCTION: Obesity is one of the major risk factors for the development of osteoarthritis (OA). Although the mechanical factors appear to be critical, recent studies have suggested a role for adipokines in cartilage degradation. Chondrocytes from osteoarthritic cartilage respond poorly to insulin...

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Detalles Bibliográficos
Autores principales: Yammani, Raghunatha R, Loeser, Richard F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392816/
https://www.ncbi.nlm.nih.gov/pubmed/22289259
http://dx.doi.org/10.1186/ar3705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392816/
https://www.ncbi.nlm.nih.gov/pubmed/22289259
http://dx.doi.org/10.1186/ar3705

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