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Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies

INTRODUCTION: Autoreactivity to histones is a pervasive feature of several human autoimmune disorders, including systemic lupus erythematosus (SLE). Specific post-translational modifications (PTMs) of histones within neutrophil extracellular traps (NETs) may potentially drive the process by which to...

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Detalles Bibliográficos
Autores principales: Liu, Chih Long, Tangsombatvisit, Stephanie, Rosenberg, Jacob M, Mandelbaum, Gil, Gillespie, Emily C, Gozani, Or P, Alizadeh, Ash A, Utz, Paul J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392818/
https://www.ncbi.nlm.nih.gov/pubmed/22300536
http://dx.doi.org/10.1186/ar3707