Assay Format as a Critical Success Factor for Identification of Novel Inhibitor Chemotypes of Tissue-Nonspecific Alkaline Phosphatase from High-Throughput Screening

The tissue-nonspecific alkaline phosphatase (TNAP) isozyme is centrally involved in the control of normal skeletal mineralization and pathophysiological abnormalities that lead to disease states such as hypophosphatasia, osteoarthritis, ankylosis and vascular calcification. TNAP acts in concert with...

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Detalles Bibliográficos
Autores principales: Chung, Thomas D.Y., Sergienko, Eduard, Millán, José Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392958/
https://www.ncbi.nlm.nih.gov/pubmed/20657462
http://dx.doi.org/10.3390/molecules15053010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392958/
https://www.ncbi.nlm.nih.gov/pubmed/20657462
http://dx.doi.org/10.3390/molecules15053010

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