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The gamma-aminobutyric acid type B (GABA(B)) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens

BACKGROUND: Repeated morphine exposure can induce behavioral sensitization. There are evidences have shown that central gamma-aminobutyric acid (GABA) system is involved in morphine dependence. However, the effect of a GABA(B) receptor agonist baclofen on morphine-induced behavioral sensitization in...

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Detalles Bibliográficos
Autores principales: Fu, Zhenyu, Yang, Hongfa, Xiao, Yuqiang, Zhao, Gang, Huang, Haiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393629/
https://www.ncbi.nlm.nih.gov/pubmed/22559224
http://dx.doi.org/10.1186/1744-9081-8-20