Shp2 Activates Fyn and Ras to Regulate RBL-2H3 Mast Cell Activation following FcεRI Aggregation

The protein-tyrosine phosphatase (PTP) Shp2 has been implicated in many immunoreceptor signaling pathways, but its role in immunoreceptor FcεRI signaling, which leads to the activation of mast cells and blood basophils, is still largely undefined. Using Shp2 knockdown RBL-2H3 (RBL) mast cells, we he...

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Detalles Bibliográficos
Autores principales: Fang, Xiaoyun, Lang, Yongjiang, Wang, Yuxiong, Mo, Wei, Wei, Huanhuan, Xie, Jianhui, Yu, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393662/
https://www.ncbi.nlm.nih.gov/pubmed/22802969
http://dx.doi.org/10.1371/journal.pone.0040566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393662/
https://www.ncbi.nlm.nih.gov/pubmed/22802969
http://dx.doi.org/10.1371/journal.pone.0040566

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