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Shp2 Activates Fyn and Ras to Regulate RBL-2H3 Mast Cell Activation following FcεRI Aggregation
The protein-tyrosine phosphatase (PTP) Shp2 has been implicated in many immunoreceptor signaling pathways, but its role in immunoreceptor FcεRI signaling, which leads to the activation of mast cells and blood basophils, is still largely undefined. Using Shp2 knockdown RBL-2H3 (RBL) mast cells, we he...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393662/ https://www.ncbi.nlm.nih.gov/pubmed/22802969 http://dx.doi.org/10.1371/journal.pone.0040566 |