Increases in Mitochondrial DNA Content and 4977-bp Deletion upon ATM/Chk2 Checkpoint Activation in HeLa Cells

Activation of the Mec1/Rad53 damage checkpoint pathway influences mitochondrial DNA (mtDNA) content and point mutagenesis in Saccharomyces cerevisiae. The effects of this conserved checkpoint pathway on mitochondrial genomes in human cells remain largely unknown. Here, we report that knockdown of th...

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Detalles Bibliográficos
Autores principales: Niu, Rong, Yoshida, Minoru, Ling, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393681/
https://www.ncbi.nlm.nih.gov/pubmed/22808196
http://dx.doi.org/10.1371/journal.pone.0040572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393681/
https://www.ncbi.nlm.nih.gov/pubmed/22808196
http://dx.doi.org/10.1371/journal.pone.0040572

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