Cargando…

Mouse-Adapted H9N2 Influenza A Virus PB2 Protein M147L and E627K Mutations Are Critical for High Virulence

H9N2 influenza viruses have been circulating worldwide in multiple avian species and have repeatedly infected humans to cause typical disease. The continued avian-to-human interspecies transmission of H9N2 viruses raises concerns about the possibility of viral adaption with increased virulence for h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Jingjing, Sun, Yipeng, Xu, Qi, Tan, Yuanyuan, Pu, Juan, Yang, Hanchun, Brown, Earl G., Liu, Jinhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393695/ https://www.ncbi.nlm.nih.gov/pubmed/22808250 http://dx.doi.org/10.1371/journal.pone.0040752

Ejemplares similares

A 627K variant in the PB2 protein of H9 subtype influenza virus in wild birds
por: Ge, Ye, et al.
Publicado: (2018)

Transmission of Influenza Virus in a Mammalian Host Is Increased by PB2 Amino Acids 627K or 627E/701N
por: Steel, John, et al.
Publicado: (2009)

A Single E627K Mutation in the PB2 Protein of H9N2 Avian Influenza Virus Increases Virulence by Inducing Higher Glucocorticoids (GCs) Level
por: Tian, Jin, et al.
Publicado: (2012)

Enhanced pathogenicity and transmissibility of H9N2 avian influenza virus in mammals by hemagglutinin mutations combined with PB2-627K
por: Liu, Kaituo, et al.
Publicado: (2022)

Role of the PB2 627 Domain in Influenza A Virus Polymerase Function
por: Nilsson, Benjamin E., et al.
Publicado: (2017)

Dual E627K and D701N mutations in the PB2 protein of A(H7N9) influenza virus increased its virulence in mammalian models
por: Zhu, Wenfei, et al.
Publicado: (2015)

The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication
por: Song, Wenjun, et al.
Publicado: (2014)

Human-like PB2 627K Influenza Virus Polymerase Activity Is Regulated by Importin-α1 and -α7
por: Hudjetz, Ben, et al.
Publicado: (2012)

Dynamic PB2-E627K substitution of influenza H7N9 virus indicates the in vivo genetic tuning and rapid host adaptation
por: Liu, William J., et al.
Publicado: (2020)

Rapid emergence of a virulent PB2 E627K variant during adaptation of highly pathogenic avian influenza H7N7 virus to mice
por: de Jong, Rineke MC, et al.
Publicado: (2013)

Influenza Polymerase Activity Correlates with the Strength of Interaction between Nucleoprotein and PB2 through the Host-Specific Residue K/E627
por: Ng, Andy Ka-Leung, et al.
Publicado: (2012)

The PB2-E627K Mutation Attenuates Viruses Containing the 2009 H1N1 Influenza Pandemic Polymerase
por: Jagger, Brett W., et al.
Publicado: (2010)

Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals
por: Liang, Libin, et al.
Publicado: (2019)

Role of Position 627 of PB2 and the Multibasic Cleavage Site of the Hemagglutinin in the Virulence of H5N1 Avian Influenza Virus in Chickens and Ducks
por: Schat, Karel A., et al.
Publicado: (2012)

NMR spectra of PB2 627, the RNA-binding domain in influenza A virus RNA polymerase that contains the pathogenicity factor lysine 627, and improvement of the spectra by small osmolytes
por: Kato, Yusuke S., et al.
Publicado: (2017)

Amino Acid Substitutions HA A150V, PA A343T, and PB2 E627K Increase the Virulence of H5N6 Influenza Virus in Mice
por: Peng, Xiuming, et al.
Publicado: (2018)

Comparative analysis of PB2 residue 627E/K/V in H5 subtypes of avian influenza viruses isolated from birds and mammals
por: Briggs, Kelsey, et al.
Publicado: (2023)

The PB2 mutation with lysine at 627 enhances the pathogenicity of avian influenza (H7N9) virus which belongs to a non-zoonotic lineage
por: Li, Weixuan, et al.
Publicado: (2017)

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit
por: Tarendeau, Franck, et al.
Publicado: (2008)

H9N2 influenza virus in China: a cause of concern
por: Sun, Yipeng, et al.
Publicado: (2014)

Guinea Pig Model for Evaluating the Potential Public Health Risk of Swine and Avian Influenza Viruses
por: Sun, Yipeng, et al.
Publicado: (2010)

Mouse-adapted H9N2 avian influenza virus causes systemic infection in mice
por: Hu, Zhe, et al.
Publicado: (2019)

Generation and protective efficacy of a cold-adapted attenuated avian H9N2 influenza vaccine
por: Wei, Yandi, et al.
Publicado: (2016)

Prevailing I292V PB2 mutation in avian influenza H9N2 virus increases viral polymerase function and attenuates IFN-β induction in human cells
por: Gao, Weihua, et al.
Publicado: (2019)

Amino acid substitutions affecting aspartic acid 605 and valine 606 decrease the interaction strength between the influenza virus RNA polymerase PB2 '627' domain and the viral nucleoprotein
por: Hsia, Ho-Pan, et al.
Publicado: (2018)

Evolution and Virulence of Influenza A Virus Protein PB1-F2
por: Kamal, Ram P., et al.
Publicado: (2017)

IS627: Radiotracer diﬀusion in refractory high-entropy alloys
por: Divinski, S V
Publicado: (2019)

CCNP security IPS 642-627 quick reference
por: Halleen, Gary
Publicado: (2011)

627. Tele-OPAT Outcomes at Two Community Hospitals
por: Sheridan, Kathleen R, et al.
Publicado: (2020)

Amino acids substitutions in the PB2 protein of H7N9 influenza A viruses are important for virulence in mammalian hosts
por: Yamayoshi, Seiya, et al.
Publicado: (2015)

CCNP Security IPS 642-627: official cert guide
por: Burns, David, et al.
Publicado: (2012)

Correction to Lancet Gastroenterol Hepatol 2022; 7: 627–47
Publicado: (2022)

PB2-Q591K Mutation Determines the Pathogenicity of Avian H9N2 Influenza Viruses for Mammalian Species
por: Wang, Congrong, et al.
Publicado: (2016)

Truncation of C-terminal 20 amino acids in PA-X contributes to adaptation of swine influenza virus in pigs
por: Xu, Guanlong, et al.
Publicado: (2016)

DNAJC2 is reversely regulated by miR-627-3p, promoting the proliferation of colorectal cancer
por: Liu, Hongfu, et al.
Publicado: (2021)

SUN-627 Unexpected Presentation of a Primary Thyroid T-Cell Lymphoma
por: Vergne-Santiago, Norma, et al.
Publicado: (2019)

SAT627 Is Cyberknife Stereotactic Radiosurgery Effective For Treating Cushing’s Disease?
por: Wintermyer, Gelareh, et al.
Publicado: (2023)

PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence
por: Wang, Guangwen, et al.
Publicado: (2022)

Effect of the Interaction between Viral PB2 and Host SphK1 on H9N2 AIV Replication in Mammals
por: Zhou, Yong, et al.
Publicado: (2022)

The infection of turkeys and chickens by reassortants derived from pandemic H1N1 2009 and avian H9N2 influenza viruses
por: Sun, Honglei, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_gq0b0l7n2p807kr1vsteecue2q