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Biophysical Mechanism of T Cell Receptor Triggering in a Reconstituted System

A T cell-mediated immune response is initiated by the T cell receptor (TCR) interacting with peptide-bound MHC (pMHC) on an infected cell. The mechanism by which this interaction triggers intracellular phosphorylation of the TCR, which lacks a kinase domain, remains poorly understood. Here, we have...

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Detalles Bibliográficos
Autores principales: James, John R., Vale, Ronald D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393772/
https://www.ncbi.nlm.nih.gov/pubmed/22763440
http://dx.doi.org/10.1038/nature11220