Transcription factor FoxO1, the dominant mediator of muscle wasting in chronic kidney disease, is inhibited by microRNA-486

Chronic kidney disease (CKD) accelerates muscle protein degradation by stimulating the ubiquitin proteasome system through activation of the E3 ligases, Atrogin-1/MaFbx and MuRF-1. Forkhead transcription factors (FoxO) can control the expression of these E3 ligases, but the contribution of individua...

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Detalles Bibliográficos
Autores principales: Xu, Jing, Li, Rongshan, Workeneh, Biruh, Dong, Yanlan, Wang, Xiaonan, Hu, Zhaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393843/
https://www.ncbi.nlm.nih.gov/pubmed/22475820
http://dx.doi.org/10.1038/ki.2012.84

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393843/
https://www.ncbi.nlm.nih.gov/pubmed/22475820
http://dx.doi.org/10.1038/ki.2012.84

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