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Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach

In the post-genome era, high throughput gene expression profiling has been successfully used to develop genomic biomarker panels (GBP) that can be integrated into clinical decision making. The development of GBPs in the context of personalized medicine is a scientifically challenging and resource-in...

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Autores principales: Shahzad, K, Fatima, A, Cadeiras, M, Wisniewski, N, Bondar, G, Cheng, R, Reed, E, Deng, MC
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394121/
https://www.ncbi.nlm.nih.gov/pubmed/23204923
http://dx.doi.org/10.2174/138920212800793339
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author Shahzad, K
Fatima, A
Cadeiras, M
Wisniewski, N
Bondar, G
Cheng, R
Reed, E
Deng, MC
author_facet Shahzad, K
Fatima, A
Cadeiras, M
Wisniewski, N
Bondar, G
Cheng, R
Reed, E
Deng, MC
author_sort Shahzad, K
collection PubMed
description In the post-genome era, high throughput gene expression profiling has been successfully used to develop genomic biomarker panels (GBP) that can be integrated into clinical decision making. The development of GBPs in the context of personalized medicine is a scientifically challenging and resource-intense process. It needs to be accomplished in a systematic phased approach to address biological variation related to a clinical phenotype (e.g. disease etiology, gender, etc.) and minimize technical variation (noise). Here we present the methodological aspects of GBP development based on the experience of the Cardiac Allograft Rejection Gene Expression Observation (CARGO) study, a study that lead to the development of a molecular classifier for rejection screening in heart transplant patients.
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spelling pubmed-33941212012-12-01 Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach Shahzad, K Fatima, A Cadeiras, M Wisniewski, N Bondar, G Cheng, R Reed, E Deng, MC Curr Genomics Article In the post-genome era, high throughput gene expression profiling has been successfully used to develop genomic biomarker panels (GBP) that can be integrated into clinical decision making. The development of GBPs in the context of personalized medicine is a scientifically challenging and resource-intense process. It needs to be accomplished in a systematic phased approach to address biological variation related to a clinical phenotype (e.g. disease etiology, gender, etc.) and minimize technical variation (noise). Here we present the methodological aspects of GBP development based on the experience of the Cardiac Allograft Rejection Gene Expression Observation (CARGO) study, a study that lead to the development of a molecular classifier for rejection screening in heart transplant patients. Bentham Science Publishers 2012-06 2012-06 /pmc/articles/PMC3394121/ /pubmed/23204923 http://dx.doi.org/10.2174/138920212800793339 Text en ©2012 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Shahzad, K
Fatima, A
Cadeiras, M
Wisniewski, N
Bondar, G
Cheng, R
Reed, E
Deng, MC
Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach
title Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach
title_full Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach
title_fullStr Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach
title_full_unstemmed Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach
title_short Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach
title_sort challenges and solutions in the development of genomic biomarker panels: a systematic phased approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394121/
https://www.ncbi.nlm.nih.gov/pubmed/23204923
http://dx.doi.org/10.2174/138920212800793339
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