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Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach
In the post-genome era, high throughput gene expression profiling has been successfully used to develop genomic biomarker panels (GBP) that can be integrated into clinical decision making. The development of GBPs in the context of personalized medicine is a scientifically challenging and resource-in...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bentham Science Publishers
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394121/ https://www.ncbi.nlm.nih.gov/pubmed/23204923 http://dx.doi.org/10.2174/138920212800793339 |
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author | Shahzad, K Fatima, A Cadeiras, M Wisniewski, N Bondar, G Cheng, R Reed, E Deng, MC |
author_facet | Shahzad, K Fatima, A Cadeiras, M Wisniewski, N Bondar, G Cheng, R Reed, E Deng, MC |
author_sort | Shahzad, K |
collection | PubMed |
description | In the post-genome era, high throughput gene expression profiling has been successfully used to develop genomic biomarker panels (GBP) that can be integrated into clinical decision making. The development of GBPs in the context of personalized medicine is a scientifically challenging and resource-intense process. It needs to be accomplished in a systematic phased approach to address biological variation related to a clinical phenotype (e.g. disease etiology, gender, etc.) and minimize technical variation (noise). Here we present the methodological aspects of GBP development based on the experience of the Cardiac Allograft Rejection Gene Expression Observation (CARGO) study, a study that lead to the development of a molecular classifier for rejection screening in heart transplant patients. |
format | Online Article Text |
id | pubmed-3394121 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-33941212012-12-01 Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach Shahzad, K Fatima, A Cadeiras, M Wisniewski, N Bondar, G Cheng, R Reed, E Deng, MC Curr Genomics Article In the post-genome era, high throughput gene expression profiling has been successfully used to develop genomic biomarker panels (GBP) that can be integrated into clinical decision making. The development of GBPs in the context of personalized medicine is a scientifically challenging and resource-intense process. It needs to be accomplished in a systematic phased approach to address biological variation related to a clinical phenotype (e.g. disease etiology, gender, etc.) and minimize technical variation (noise). Here we present the methodological aspects of GBP development based on the experience of the Cardiac Allograft Rejection Gene Expression Observation (CARGO) study, a study that lead to the development of a molecular classifier for rejection screening in heart transplant patients. Bentham Science Publishers 2012-06 2012-06 /pmc/articles/PMC3394121/ /pubmed/23204923 http://dx.doi.org/10.2174/138920212800793339 Text en ©2012 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Shahzad, K Fatima, A Cadeiras, M Wisniewski, N Bondar, G Cheng, R Reed, E Deng, MC Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach |
title | Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach |
title_full | Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach |
title_fullStr | Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach |
title_full_unstemmed | Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach |
title_short | Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach |
title_sort | challenges and solutions in the development of genomic biomarker panels: a systematic phased approach |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394121/ https://www.ncbi.nlm.nih.gov/pubmed/23204923 http://dx.doi.org/10.2174/138920212800793339 |
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