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The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation

BACKGROUND: Prion diseases are neurodegenerative disorders characterized by the accumulation of an abnormal disease-associated prion protein, PrP(Sc). In prion-infected brains, activated microglia are often present in the vicinity of PrP(Sc) aggregates, and microglial activation is thought to play a...

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Detalles Bibliográficos
Autores principales:	Shi, Fushan, Yang, Lifeng, Kouadir, Mohammed, Yang, Yang, Wang, Jihong, Zhou, Xiangmei, Yin, Xiaomin, Zhao, Deming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394218/ https://www.ncbi.nlm.nih.gov/pubmed/22531291 http://dx.doi.org/10.1186/1742-2094-9-73

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