(V600E)Braf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16(INK4a)

The majority of human colorectal cancers (CRCs) are initiated by mutations arising in the adenomatous polyposis coli (APC) tumour suppressor gene. However, a new class of non-APC mutated CRCs has been defined that have a serrated histopathology and carry the (V600E)BRAF oncogene. Here we have invest...

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Detalles Bibliográficos
Autores principales: Carragher, Linda A S, Snell, Kimberley R, Giblett, Susan M, Aldridge, Victoria S S, Patel, Bipin, Cook, Simon J, Winton, Doug J, Marais, Richard, Pritchard, Catrin A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394506/
https://www.ncbi.nlm.nih.gov/pubmed/20941790
http://dx.doi.org/10.1002/emmm.201000099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394506/
https://www.ncbi.nlm.nih.gov/pubmed/20941790
http://dx.doi.org/10.1002/emmm.201000099

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