Morphine-induced mu opioid receptor trafficking enhances reward yet prevents compulsive drug use

Morphine, heroin and other commonly abused opioids induce little mu opioid receptor (MOR) trafficking compared to endogenous opioids. We utilized knock-in mice expressing a mutant recycling MOR (RMOR) that desensitizes and is internalized in response to morphine to show that facilitating MOR traffic...

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Detalles Bibliográficos
Autores principales: Berger, Amy Chang, Whistler, Jennifer L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394511/
https://www.ncbi.nlm.nih.gov/pubmed/21656686
http://dx.doi.org/10.1002/emmm.201100144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394511/
https://www.ncbi.nlm.nih.gov/pubmed/21656686
http://dx.doi.org/10.1002/emmm.201100144

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