Calcium Binding Promotes Prion Protein Fragment 90–231 Conformational Change toward a Membrane Destabilizing and Cytotoxic Structure

The pathological form of prion protein (PrP(Sc)), as other amyloidogenic proteins, causes a marked increase of membrane permeability. PrP(Sc) extracted from infected Syrian hamster brains induces a considerable change in membrane ionic conductance, although the contribution of this interaction to th...

Descripción completa

Detalles Bibliográficos
Autores principales: Sorrentino, Sacha, Bucciarelli, Tonino, Corsaro, Alessandro, Tosatto, Alessio, Thellung, Stefano, Villa, Valentina, Schininà, M. Eugenia, Maras, Bruno, Galeno, Roberta, Scotti, Luca, Creati, Francesco, Marrone, Alessandro, Re, Nazzareno, Aceto, Antonio, Florio, Tullio, Mazzanti, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394757/
https://www.ncbi.nlm.nih.gov/pubmed/22811758
http://dx.doi.org/10.1371/journal.pone.0038314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394757/
https://www.ncbi.nlm.nih.gov/pubmed/22811758
http://dx.doi.org/10.1371/journal.pone.0038314

Ejemplares similares