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Calcium Binding Promotes Prion Protein Fragment 90–231 Conformational Change toward a Membrane Destabilizing and Cytotoxic Structure

The pathological form of prion protein (PrP(Sc)), as other amyloidogenic proteins, causes a marked increase of membrane permeability. PrP(Sc) extracted from infected Syrian hamster brains induces a considerable change in membrane ionic conductance, although the contribution of this interaction to th...

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Detalles Bibliográficos
Autores principales:	Sorrentino, Sacha, Bucciarelli, Tonino, Corsaro, Alessandro, Tosatto, Alessio, Thellung, Stefano, Villa, Valentina, Schininà, M. Eugenia, Maras, Bruno, Galeno, Roberta, Scotti, Luca, Creati, Francesco, Marrone, Alessandro, Re, Nazzareno, Aceto, Antonio, Florio, Tullio, Mazzanti, Michele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394757/ https://www.ncbi.nlm.nih.gov/pubmed/22811758 http://dx.doi.org/10.1371/journal.pone.0038314

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