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3′-Processing and strand transfer catalysed by retroviral integrase in crystallo
Retroviral integrase (IN) is responsible for two consecutive reactions, which lead to insertion of a viral DNA copy into a host cell chromosome. Initially, the enzyme removes di- or trinucleotides from viral DNA ends to expose 3′-hydroxyls attached to the invariant CA dinucleotides (3′-processing re...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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European Molecular Biology Organization
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395085/ https://www.ncbi.nlm.nih.gov/pubmed/22580823 http://dx.doi.org/10.1038/emboj.2012.118 |