The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress

The p57(Kip2) cyclin-dependent kinase inhibitor (CDKi) has been implicated in embryogenesis, stem-cell senescence and pathologies, but little is known of its role in cell cycle control. Here, we show that p57(Kip2) is targeted by the p38 stress-activated protein kinase (SAPK). Phosphorylation of p57...

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Detalles Bibliográficos
Autores principales: Joaquin, Manel, Gubern, Albert, González-Nuñez, Daniel, Josué Ruiz, E, Ferreiro, Isabel, de Nadal, Eulalia, Nebreda, Angel R, Posas, Francesc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395087/
https://www.ncbi.nlm.nih.gov/pubmed/22569127
http://dx.doi.org/10.1038/emboj.2012.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395087/
https://www.ncbi.nlm.nih.gov/pubmed/22569127
http://dx.doi.org/10.1038/emboj.2012.122

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