Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

In normal human somatic cells, telomere dysfunction causes cellular senescence, a stable proliferative arrest with tumour suppressing properties. Whether telomere dysfunction-induced senescence (TDIS) suppresses cancer growth in humans, however, is unknown. Here, we demonstrate that multiple and dis...

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Detalles Bibliográficos
Autores principales: Suram, Anitha, Kaplunov, Jessica, Patel, Priyanka L, Ruan, Haihe, Cerutti, Aurora, Boccardi, Virginia, Fumagalli, Marzia, Di Micco, Raffaella, Mirani, Neena, Gurung, Resham Lal, Hande, Manoor Prakash, d’Adda di Fagagna, Fabrizio, Herbig, Utz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395091/
https://www.ncbi.nlm.nih.gov/pubmed/22569128
http://dx.doi.org/10.1038/emboj.2012.132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395091/
https://www.ncbi.nlm.nih.gov/pubmed/22569128
http://dx.doi.org/10.1038/emboj.2012.132

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