miRNA-like duplexes as RNAi triggers with improved specificity

siRNA duplexes, the most common triggers of RNA interference, are first loaded into an Argonaute (Ago) protein and then undergo unwinding via passenger strand cleavage, which requires the slicer activity of the Ago protein. In mammals, only Ago2 out of the four Ago proteins possesses such slicer act...

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Detalles Bibliográficos
Autores principales: Betancur, Juan G., Yoda, Mayuko, Tomari, Yukihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395129/
https://www.ncbi.nlm.nih.gov/pubmed/22807929
http://dx.doi.org/10.3389/fgene.2012.00127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395129/
https://www.ncbi.nlm.nih.gov/pubmed/22807929
http://dx.doi.org/10.3389/fgene.2012.00127

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