Pathological Roles of Wild-Type Cu, Zn-Superoxide Dismutase in Amyotrophic Lateral Sclerosis

Dominant mutations in a Cu, Zn-superoxide dismutase (SOD1) gene cause a familial form of amyotrophic lateral sclerosis (ALS). While it remains controversial how SOD1 mutations lead to onset and progression of the disease, many in vitro and in vivo studies have supported a gain-of-toxicity mechanism...

Descripción completa

Detalles Bibliográficos
Autor principal: Furukawa, Yoshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395178/
https://www.ncbi.nlm.nih.gov/pubmed/22830015
http://dx.doi.org/10.1155/2012/323261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395178/
https://www.ncbi.nlm.nih.gov/pubmed/22830015
http://dx.doi.org/10.1155/2012/323261

Ejemplares similares