Effect of Graded Nrf2 Activation on Phase-I and -II Drug Metabolizing Enzymes and Transporters in Mouse Liver

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a battery of cytoprotective genes in response to oxidative/electrophilic stress. Kelch-like ECH associating protein 1 (Keap1) sequesters Nrf2 in the cytosol. The purpose of this study was to investigate the rol...

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Detalles Bibliográficos
Autores principales: Wu, Kai Connie, Cui, Julia Yue, Klaassen, Curtis D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395627/
https://www.ncbi.nlm.nih.gov/pubmed/22808024
http://dx.doi.org/10.1371/journal.pone.0039006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395627/
https://www.ncbi.nlm.nih.gov/pubmed/22808024
http://dx.doi.org/10.1371/journal.pone.0039006

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