Cargando…

Effect of Graded Nrf2 Activation on Phase-I and -II Drug Metabolizing Enzymes and Transporters in Mouse Liver

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a battery of cytoprotective genes in response to oxidative/electrophilic stress. Kelch-like ECH associating protein 1 (Keap1) sequesters Nrf2 in the cytosol. The purpose of this study was to investigate the rol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Kai Connie, Cui, Julia Yue, Klaassen, Curtis D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395627/ https://www.ncbi.nlm.nih.gov/pubmed/22808024 http://dx.doi.org/10.1371/journal.pone.0039006

Ejemplares similares

Genetic Activation of Nrf2 Protects against Fasting-Induced Oxidative Stress in Livers of Mice
por: Zhang, Yu-Kun Jennifer, et al.
Publicado: (2013)

NRF2 Protection against Liver Injury Produced by Various Hepatotoxicants
por: Liu, Jie, et al.
Publicado: (2013)

ChIPing the cistrome of PXR in mouse liver
por: Cui, Julia Yue, et al.
Publicado: (2010)

Deciphering the Developmental Dynamics of the Mouse Liver Transcriptome
por: Gunewardena, Sumedha S., et al.
Publicado: (2015)

Diurnal Variations of Mouse Plasma and Hepatic Bile Acid Concentrations as well as Expression of Biosynthetic Enzymes and Transporters
por: Zhang, Yu-Kun Jennifer, et al.
Publicado: (2011)

Overexpression of Nrf2 Protects against Microcystin-Induced Hepatotoxicity in Mice
por: Lu, Yuan-Fu, et al.
Publicado: (2014)

Implementation of a High-Throughput Screen for Identifying Small Molecules to Activate the Keap1-Nrf2-ARE Pathway
por: Wu, Kai Connie, et al.
Publicado: (2012)

Zeaxanthin induces Nrf2-mediated phase II enzymes in protection of cell death
por: Zou, X, et al.
Publicado: (2014)

Effect of Diet on Expression of Genes Involved in Lipid Metabolism, Oxidative Stress, and Inflammation in Mouse Liver–Insights into Mechanisms of Hepatic Steatosis
por: Renaud, Helen J., et al.
Publicado: (2014)

Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting
por: van den Bosch, Heleen M, et al.
Publicado: (2007)

Characterizing drug-metabolizing enzymes and transporters that are bona fide CAR-target genes in mouse intestine
por: Park, Shinhee, et al.
Publicado: (2016)

Polymorphisms of Phase I and Phase II Enzymes and Breast Cancer Risk
por: Justenhoven, Christina
Publicado: (2012)

Transactivation of Genes Encoding for Phase II Enzymes and Phase III Transporters by Phytochemical Antioxidants
por: Yang, Yoon Mee, et al.
Publicado: (2010)

Piper betle induces phase I & II genes through Nrf2/ARE signaling pathway in mouse embryonic fibroblasts derived from wild type and Nrf2 knockout cells
por: Wan Hasan, Wan Nuraini, et al.
Publicado: (2014)

Role of farnesoid X receptor in establishment of ontogeny of phase-I drug metabolizing enzyme genes in mouse liver
por: Peng, Lai, et al.
Publicado: (2016)

Zearalenone Induces Endoplasmic Reticulum Stress and Modulates the Expression of Phase I/II Enzymes in Human Liver Cells
por: Yoon, Jee Eun, et al.
Publicado: (2019)

Induction by Phenobarbital of Phase I and II Xenobiotic-Metabolizing Enzymes in Bovine Liver: An Overall Catalytic and Immunochemical Characterization
por: Cantiello, Michela, et al.
Publicado: (2022)

Polybacterial Periodontal Pathogens Alter Vascular and Gut BH(4)/nNOS/NRF2-Phase II Enzyme Expression
por: Gangula, Pandu, et al.
Publicado: (2015)

Icariside II Enhances Nrf2 Nuclear Translocation to Upregulate Phase II Detoxifying Enzyme Expression Coupled with the ERK, Akt and JNK Signaling Pathways
por: Gu, Jing, et al.
Publicado: (2011)

Yinchenhao Decoction Ameliorates Alpha-Naphthylisothiocyanate Induced Intrahepatic Cholestasis in Rats by Regulating Phase II Metabolic Enzymes and Transporters
por: Yi, Ya-Xiong, et al.
Publicado: (2018)

The Role of Sirt1 in Bile Acid Regulation during Calorie Restriction in Mice
por: Fu, Zidong Donna, et al.
Publicado: (2015)

EXPERIMENTAL LIVER NECROSIS; II. ENZYMES
por: Pearce, Richard M., et al.
Publicado: (1907)

Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor
por: Rooney, John, et al.
Publicado: (2018)

miR-503 Is Involved in the Protective Effect of Phase II Enzyme Inducer (CPDT) in Diabetic Cardiomyopathy via Nrf2/ARE Signaling Pathway
por: Miao, Ying, et al.
Publicado: (2017)

Astaxanthin Protects Human Granulosa Cells against Oxidative Stress through Activation of NRF2/ARE Pathway and Its Downstream Phase II Enzymes
por: Eslami, Mojtaba, et al.
Publicado: (2021)

Effects of stachyose on absorption and transportation of tea catechins in mice: possible role of Phase II metabolic enzymes and efflux transporters inhibition by stachyose
por: Li, Wenfeng, et al.
Publicado: (2016)

Safety and efficacy of aged garlic extract in dogs: upregulation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway and Nrf2-regulated phase II antioxidant enzymes
por: Yamato, Osamu, et al.
Publicado: (2018)

Bone Marrow Mesenchymal Stem Cells in Acute-on-Chronic Liver Failure Grades 2 and 3: A Phase I-II Randomized Clinical Trial
por: Schacher, Fernando Comunello, et al.
Publicado: (2021)

Phase I/II clinical trial of enzyme replacement therapy with idursulfase beta in patients with mucopolysaccharidosis II (Hunter Syndrome)
por: Sohn, Young Bae, et al.
Publicado: (2013)

A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during Pregnancy
por: Gong, Christine, et al.
Publicado: (2023)

Regulation of Nrf2-Mediated Phase II Detoxification and Anti-oxidant Genes
por: Keum, Young-Sam
Publicado: (2012)

Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II
por: Jarolim, Katharina, et al.
Publicado: (2016)

Dual Role of Dietary Curcumin Through Attenuating AFB(1)-Induced Oxidative Stress and Liver Injury via Modulating Liver Phase-I and Phase-II Enzymes Involved in AFB(1) Bioactivation and Detoxification
por: Muhammad, Ishfaq, et al.
Publicado: (2018)

Comparative Study of Hydroxytyrosol Acetate and Hydroxytyrosol in Activating Phase II Enzymes
por: Zou, Xuan, et al.
Publicado: (2023)

First experiences in treatment of low-grade glioma grade I and II with proton therapy
por: Hauswald, Henrik, et al.
Publicado: (2012)

Phase I and Phase II CMS upgrade
por: Heister, A
Publicado: (2014)

Protopanaxatriol Ginsenoside Rh1 Upregulates Phase II Antioxidant Enzyme Gene Expression in Rat Primary Astrocytes: Involvement of MAP Kinases and Nrf2/ARE Signaling
por: Jung, Ji-Sun, et al.
Publicado: (2016)

Subgroup‐specific dose finding for phase I‐II trials using Bayesian clustering
por: Curtis, Alexandra, et al.
Publicado: (2022)

Low dose of luteolin activates Nrf2 in the liver of mice at start of the active phase but not that of the inactive phase
por: Kitakaze, Tomoya, et al.
Publicado: (2020)

Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway
por: He, Jin-Lian, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_315f4vmimujuvk3id0p7g76ok1