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Mechanisms of GnRH-Induced Extracellular Signal-Regulated Kinase Nuclear Localization

Gonadotropin-releasing hormone receptors (GnRHR) mediate activation and nuclear translocation of the extracellular signal regulated kinases 1 and 2 (ERK) by phosphorylation on the TEY motif. This is necessary for GnRH to initiate transcriptional programmes controlling fertility, but mechanisms that...

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Detalles Bibliográficos
Autores principales: Caunt, Christopher J., Perett, Rebecca M., Fowkes, Robert C., McArdle, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395631/
https://www.ncbi.nlm.nih.gov/pubmed/22808094
http://dx.doi.org/10.1371/journal.pone.0040077