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Calcium-calmodulin kinase I cooperatively regulates nucleocytoplasmic shuttling of CCTα by accessing a nuclear export signal

We identified a new calmodulin kinase I (CaMKI) substrate, cytidyltransferase (CCTα), a crucial enzyme required for maintenance of cell membranes. CCTα becomes activated with translocation from the cytoplasm to the nuclear membrane, resulting in increased membrane phospholipids. Calcium-activated CC...

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Detalles Bibliográficos
Autores principales: Agassandian, Marianna, Chen, Bill B., Pulijala, Roopa, Kaercher, Leah, Glasser, Jennifer R., Mallampalli, Rama K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395663/
https://www.ncbi.nlm.nih.gov/pubmed/22621903
http://dx.doi.org/10.1091/mbc.E11-10-0863