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Compensatory Evolution of Net-Charge in Influenza A Virus Hemagglutinin
The propagation of influenza A virus depends on the balance between the activities of hemagglutinin (HA) for binding to host cells and neuraminidase (NA) for releasing from infected cells (HA-NA balance). Since the host cell membrane and the sialic acid receptor are negatively charged, the amino aci...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395715/ https://www.ncbi.nlm.nih.gov/pubmed/22808159 http://dx.doi.org/10.1371/journal.pone.0040422 |