Reorganization of the host epigenome by a viral oncogene

Adenovirus small e1a oncoprotein causes ∼70% reduction in cellular levels of histone H3 lysine 18 acetylation (H3K18ac). It is unclear, however, where this dramatic reduction occurs genome-wide. ChIP-sequencing revealed that by 24 h after expression, e1a erases 95% of H3K18ac peaks in normal, contac...

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Detalles Bibliográficos
Autores principales: Ferrari, Roberto, Su, Trent, Li, Bing, Bonora, Giancarlo, Oberai, Amit, Chan, Yvonne, Sasidharan, Rajkumar, Berk, Arnold J., Pellegrini, Matteo, Kurdistani, Siavash K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396363/
https://www.ncbi.nlm.nih.gov/pubmed/22499665
http://dx.doi.org/10.1101/gr.132308.111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396363/
https://www.ncbi.nlm.nih.gov/pubmed/22499665
http://dx.doi.org/10.1101/gr.132308.111

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